Antibodies binding to an intracellular prl-1 or prl-3...

A - Human Necessities – 61 – K

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Details

A61K 39/395 (2006.01) A61P 35/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2685954

We provide an antibody capable of binding to an intracellular PRL-I or PRL-3 polypeptide, in which the antibody is capable of binding to an epitope bound by antibody 269, antibody 223 or antibody 318. Such anti-PRL antibodies may be capable of binding to intracellular PRL-I or PRL-3. They may be suitable for use as therapies against cancer or metastasis thereof, or in clinical diagnosis to identify PRL-3 or PRL-I positive patients.

Nous proposons un anticorps capable de se lier à un polypeptide PRL-I ou PRL-3 intracellulaire, dans lequel l'anticorps est capable de se lier à un épitope lié par un anticorps 269, un anticorps 223 ou un anticorps 318. De tels anticorps anti-PRL peuvent se lier à PRL-I ou PRL-3 intracellulaire. Ils peuvent être appropriés pour une utilisation en tant que thérapies contre le cancer ou une métastase de celui-ci, ou dans un diagnostic clinique pour identifier des patients positifs à PRL-3 ou PRL-I.

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