C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) A61P 37/02 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 15/63 (2006.01) C12P 21/08 (2006.01)
Patent
CA 2601417
Compositions and methods for regulating an immune response in a subject are de~scribed. More particularly, described are human antibodies that regulate the activity of NK cells and allow a potentiation of NK cell cytotoxicity in mammalian subjects, and antibodies having antigen-binding properties similar to those of human monoclonal antibody 1-7F9 or 1~4F1. Described also are also fragments and derivatives of such antibodies, as well as phar~maceutical compositions comprising the same and their uses, particularly for use in therapy, to increase NK cell activity or cytotoxicity in subjects.
L'invention concerne des compositions et des procédés qui permettent de réguler une réponse immunitaire chez un sujet. En particulier, l'invention porte sur des anticorps humains qui régulent l'activité des cellules NK et permettent de potentialiser la cytotoxicité des cellules NK chez des sujets mammaliens, et sur des anticorps possédant des activités de liaison à l'antigène similaires à celles de l'anticorps monoclonal humain 1-7F9 ou 1-4F1. L'invention se rapporte également à des fragments et des dérivés des anticorps précités, et à des compositions pharmaceutiques renfermant ces derniers et à leurs utilisations, en particulier en thérapie, pour augmenter l'activité ou la cytotoxicité des cellules NK chez des sujets.
Andre Pascale
Berg Padkaer Soeren
Chiesa Mariella Della
Gauthier Laurent
Kjaergaard Kristian
Dimock Stratton Llp
Innate Pharma
Novo Nordisk A/s
University Of Genoa
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