Antibodies containing therapeutic tpo/epo mimetic peptides

Details Antibodies containing therapeutic tpo/epo mimetic peptides Antibodies containing therapeutic tpo/epo mimetic peptides

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) C07K 14/475 (2006.01) C07K 14/505 (2006.01) C07K 16/00 (2006.01) C12N 1/21 (2006.01) C12N 15/13 (2006.01) C12N 15/62 (2006.01) C12N 15/70 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2753438

The present disclosure features therapeutic antibodies (e.g., TPO mimetic antibodies) and therapeutically-active fragments thereof as well as methods for preparing and using the antibodies and fragments. For example, the therapeutic antibodies and their fragments are useful in a variety of diagnostic and/or therapeutic applications such as methods for increasing platelet levels in a subject.

La présente invention porte sur des anticorps thérapeutiques (par exemple, anticorps mimétiques de TPO) et sur des fragments thérapeutiquement actifs de ceux-ci, ainsi que sur des procédés de préparation et d'utilisation des anticorps et des fragments. Par exemple, les anticorps thérapeutiques et leurs fragments sont utiles dans une diversité d'applications de diagnostic et/ou thérapeutiques, telles que des procédés pour augmenter les taux de plaquettes chez un sujet.

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