Antibodies directed against an ldl receptor

Details Antibodies directed against an ldl receptor Antibodies directed against an ldl receptor

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01) C12N 5/20 (2006.01) C12N 15/13 (2006.01) C12N 15/63 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2618050

The invention relates to a monoclonal antibody directed against a human LDL (Low Density Lipoprotein) receptor bound to a corresponding peptide of 195-222 (SEQ ID NO: 1) amino acids of the LDL receptor peptide sequence, to the use thereof in the form of a drug, to a pharmaceutical composition containing said antibody and to the use thereof in immune-histochemical analysis of cancerous, healthy or cirrhosis-free or cirrhosis tissues in western blot, ELISA or in an in vivo quantification tests.

La présente invention concerne un anticorps monoclonal dirigé contre le récepteur humain des LDL (Low Density Lipoprotein), se liant au peptide correspondant aux acides aminés 280-307 (SEQ ID NO : 1) de la séquence peptidique du récepteur des LDL, son utilisation comme médicament, une composition pharmaceutique contenant cet anticorps, ainsi que son utilisation dans les analyses immunohistochimiques de tissus cancéreux, sains ou cirrhoses, en western blot, en ELISA ou en test de quantification in vivo.

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