Antibodies directed against binding-associated epitopes

Details Antibodies directed against binding-associated epitopes Antibodies directed against binding-associated epitopes

C - Chemistry, Metallurgy

12

N

C12N 5/18 (2006.01) A61K 39/21 (2006.01) A61K 39/42 (2006.01) A61K 47/48 (2006.01) C07K 14/155 (2006.01) C07K 16/10 (2006.01) C07K 16/28 (2006.01) C07K 16/42 (2006.01) G01N 33/569 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2152915

Binding of two members of a binding couple reveals epitopes which are revealed only after binding and antibodies directed against these epitopes bind to the bound couple at a significantly higher affinity than their binding affinity to either of the two members themselves when not bound to one another. The novel epitope and the antibodies of the invention have various therapeutic and diagnostic applications such as treatment and immunization against viral diseases.

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