Antibodies directed to av.beta.6 and uses thereof

Details Antibodies directed to av.beta.6 and uses thereof Antibodies directed to av.beta.6 and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) C12N 5/00 (2006.01) C12N 15/13 (2006.01)

Patent

CA 2658612

Targeted binding agents, such antibodies directed to the antigen .alpha.V.beta.6 and uses of such agents are described. In particular, fully human monoclonal antibodies directed to the antigen .alpha.V.beta.6 are disclosed. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3 are disclosed. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also disclosed.

L'invention concerne des agents de liaison ciblés, tels que des anticorps dirigés contre l'antigène .alpha.V.beta.6, et les utilisations de tels agents. L'invention concerne notamment des anticorps monoclonaux totalement humains dirigés contre l'antigène .alpha.V.beta.6. L'invention concerne également des séquences de nucléotides codant pour, et des séquences d'acides aminés comprenant, des molécules d'immunoglobuline à chaînes légères et lourdes, notamment des séquences correspondant à des séquences de chaînes légères et lourdes contiguës s'étendant sur les régions structurales et/ou les régions déterminantes de la complémentarité (CDR), notamment de FR1 à FR4 ou de CDR1 à CDR3. L'invention concerne également des hybridomes ou d'autres lignées cellulaires qui expriment de telles molécules d'immunoglobuline et des anticorps monoclonaux.

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