Antibodies directed to cd20 and uses thereof

Details Antibodies directed to cd20 and uses thereof Antibodies directed to cd20 and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2610234

Antibodies directed to the antigen CD20 and uses of such antibodies are disclosed herein. In particular, fully human monoclonal antibodies directed to the antigen CD20. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3 are disclosed. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also disclosed.

L'invention concerne des anticorps dirigés contre l'antigène CD20 et les utilisations de ces anticorps et, d'une manière plus spécifique, des anticorps monoclonaux pleinement humains dirigés contre l'antigène CD20. L'invention concerne également les séquences nucléotidiques codant pour, et des séquences d'acides aminés comprenant, des molécules d'immunoglobuline à chaînes lourdes et légères, notamment des séquences correspondant aux séquences de chaînes lourdes et légères contiguës couvrant les couvrant les régions de charpente et/ou les régions de détermination de la complémentarité (CDR), spécifiquement de FR1 à FR4 ou de CDR1 à CDR3. L'invention concerne enfin des hybridomes ou d'autres lignées cellulaires exprimant ces molécules d'immunoglobuline et ces anticorps monoclonaux.

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