C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07K 16/30 (2006.01) C07K 19/00 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01)
Patent
CA 2589374
The present invention provides fully human monoclonal antibodies that specifically bind to GPNMB, and uses thereof. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDRs) are provided. The present invention also provides immunoconjugates comprising anti-GPNMB antibodies and methods of using such immunoconjugates. The present invention further provides bispecific antibodies comprising an anti-GPNMB antibody component and an anti-CD3 component, and methods of using such bispecific antibodies.
La présente invention a trait à des anticorps monoclonaux entièrement humains de liaison spécifique à la GPNMB, et leurs utilisations. L'invention a également trait à des séquences nucléotidiques codant pour, et des séquences d'acides aminés comportant, des molécules d'immunoglobuline de chaîne lourde et légère, notamment des séquences correspondant à des séquences contiguës de chaîne lourde et légère s'étendant sur les régions d'encadrement et/ou des régions de déterminant la complémentarité. La présente invention a trait en outre à des immunoconjugués comprenant des anticorps anti-GPNMB et à des procédés d'utilisation de tels immunoconjugués. La présente invention a trait enfin à des anticorps bispécifiques comprenant un anticorps anti-GPNMB et un constituant anti-GPNMB, et à des procédés d'utilisation de tels anticorps bispécifiques.
Ara Gulshan
Chapoval Andrei
Davagnino Juan
Foord Orit
Herrmann John
Abgenix Inc.
Curagen Corporation
Ridout & Maybee Llp
LandOfFree
Antibodies directed to gpnmb and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Antibodies directed to gpnmb and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antibodies directed to gpnmb and uses thereof will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-2040097