Antibodies directed to her-3 and uses thereof

Details Antibodies directed to her-3 and uses thereof Antibodies directed to her-3 and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 16/32 (2006.01)

Patent

CA 2633222

The present invention relates to binding proteins that bind to HER-3 and polynucleotides encoding the same. Ex- pression vectors and host cells comprising the same for the production of the binding protein of the invention are also provided. In addition, the invention provides compositions and methods for diagnosing and treating diseases associated with HER-3 mediated signal transduction and/or its ligand heregulin.

La présente invention concerne des protéines de liaison qui se lient au HER-3, ainsi que des polynucléotides codant pour ces protéines. L'invention concerne également des vecteurs d'expression et des cellules hôtes contenant ces vecteurs pour la production de la protéine de liaison de l'invention. En outre, l'invention concerne des compositions et des procédés de diagnostic et de traitement de maladies associées à la transduction du signal médiée par le HER-3 et/ou son ligand héréguline.

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