C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/24 (2006.01) A61K 39/395 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2496419
Embodiments of the invention described herein relate to antibodies directed to the antigen monocyte chemo-attractant protein-1 (MCP-1) and uses of such antibodies. In particular, in accordance with some embodiments, there are provided fully human monoclonal antibodies directed to the antigen MCP-1. Nucelotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDRs), specifically from FR1 through FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.
Dans certains modes de réalisation, l'invention concerne des anticorps dirigés contre la protéine chimioattractive monocytaire 1 d'antigène (MCP-1) entièrement humain et leurs utilisations. Dans d'autres modes de réalisation, l'invention concerne, en particulier, des anticorps monoclonaux dirigés contre la MCP-1 d'antigène. L'invention concerne également le codage de séquences nucléotidiques, et des séquences d'acides aminés comprenant des molécules d'immunoglobuline à chaîne lourde et légère, en particulier, des séquences correspondant aux séquences contiguës à chaîne lourde et légère s'étalant dans les régions structurales et/ou des régions de détermination de complémentarité (CDR), en particulier, de FR1 à FR4 ou de CDR1 à CDR3. L'invention concerne enfin des hybridomes ou d'autres lignées cellulaires exprimant les molécules d'immunoglobuline et les anticorps monoclonaux.
Ahluwalia Kiran
Bhakta Sunil
Foord Orit
Gudas Jean M.
Haak-Frendscho Mary
Abgenix Inc.
Astrazeneca Ab
Smart & Biggar
LandOfFree
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