A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) C07K 16/28 (2006.01) C07K 17/00 (2006.01)
Patent
CA 2530285
The present invention relates to novel antibodies, particularly antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to the type III deletion mutant, EGFRvIII. The invention also relates to human monoclonal antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to EGFRvIII. Diagnostic and therapeutic formulations of such antibodies, and immunoconjugates thereof, are also provided.
La présente invention se rapporte à de nouveaux anticorps, notamment à des anticorps dirigés contre les mutants de délétion du récepteur du facteur de croissance épidermique, et notamment le mutant de délétion de type III, EGFRvIII. L'invention se rapporte également à des anticorps monoclonaux humains dirigés contre les mutants de délétion du récepteur du facteur de croissance épidermique, notamment EGFRvIII. L'invention se rapporte en outre à des formulations diagnostiques et thérapeutiques de ces anticorps, et d'immunoconjugués de ces anticorps.
Corvalan Jose
Feng Xiao
Foltz Ian
Foord Orit
Green Larry
Abgenix Inc.
Amgen Fremont Inc.
Smart & Biggar
LandOfFree
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