C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 39/395 (2006.01) C07K 14/71 (2006.01) C07K 16/28 (2006.01) C07K 19/00 (2006.01) C12N 5/12 (2006.01) C12N 5/16 (2006.01) G01N 33/53 (2006.01) G01N 33/533 (2006.01) G01N 33/534 (2006.01) G01N 33/535 (2006.01)
Patent
CA 2530172
The present invention relates to novel antibodies, particularly antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to the type III deletion mutant, EGFRvIII. The invention also relates to human monoclonal antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to EGFRvIII. Diagnostic and therapeutic formulations of such antibodies, and immunoconjugates thereof, are also provided.
La présente invention concerne de nouveau anticorps, en particulier des anticorps utilisés contre les mutants de délétion du récepteur du facteur de croissance épidermique, et en particulier le mutant de délétion de type III EGFRvIII. L'invention concerne également des anticorps monoclonaux humains utilisés contre les mutants de délétion du récepteur du facteur de croissance épidermique, et en particulier EGFRvIII. L'invention concerne en outre des formulations diagnostiques et thérapeutiques desdits anticorps, ainsi que des immunoconjugués de ceux-ci.
Corvalan Jose
Feng Xiao
Foltz Ian
Foord Orit
Green Larry
Abgenix Inc.
Amgen Fremont Inc.
Smart & Biggar
LandOfFree
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