Antibodies directed to tumor necrosis factor and uses thereof

Details Antibodies directed to tumor necrosis factor and uses thereof Antibodies directed to tumor necrosis factor and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 16/24 (2006.01) A61K 39/395 (2006.01) A61P 37/02 (2006.01) C07K 16/00 (2006.01) C12N 15/13 (2006.01)

Patent

CA 2508375

Antibodies directed to the antigen TNFa and uses of such antibodies. In particular, fully human monoclonal antibodies directed to the antigen TNFa. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies.

Cette invention concerne des anticorps agissant sur l'antigène TNF et leurs utilisations. L'invention concerne en particulier : des anticorps monoclonaux entièrement humains agissant sur l'antigène TNFa; des séquences de nucléotides codant pour, et des séquences d'acides aminés comprenant, des molécules d'immunoglobuline à chaînes lourde et légère, en particulier des séquences correspondant aux chaînes contiguës lourdes et légères occupant les régions structurales et/ou les régions hypervariables (CDR), specifiquement de FR1 à FR4 ou de CDR1 à CDR3; des hybridomes ou autres lignées cellulaires exprimant de telles molécules d'immunoglobuline et d'anticorps monoclonaux.

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