C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/12 (2006.01) C07K 16/02 (2006.01)
Patent
CA 2479270
The present invention relates to antibodies immunologically specific for an attaching and effacing Escherichia coli (AEEC) virulence-associated protein, products, compositions and methods and to their use thereof in the prevention of an AEEC infection in a mammal. The antibody of the invention is immunologically specific for an AEEC virulence-associated protein and is capable of preventing an in vivo AEEC intestinal infection when administered to a mammal. The antibody of the invention is preferably useful for preventing the development of A/E intestinal lesions associated with the AEEC. This is achieved by preferably using lgY antibodies immunologically specific for one or more AEEC virulence-associated proteins, such as Eae, Tir, EspA and Paa.
L'invention concerne des anticorps immunologiquement sp~cifiques de prot~ine associ~e ~ la virulence de souches d'Escherichia coli attachantes et effa×antes (AEEC), des produits, des compositions contenant ces anticorps, ainsi que leurs proc~d~s d'utilisation dans la pr~vention d'une infection par AEEC chez un mammifre. L'anticorps de l'invention est immunologiquement sp~cifique d'une prot~ine associ~e ~ la virulence d'AEEC et, administr~ ~ un mammifre, permet d'~viter une infection intestinale due ~ une souche d'AEEC in vivo. Cet anticorps est utilis~, de pr~f~rence, pour la pr~vention du d~veloppement de l~sions intestinales d'attachement/effacement associ~es ~ une souche d'AEEC. On obtient ce r~sultat en utilisant, de pr~f~rence, des anticorps lgY immunologiquement sp~cifiques pour une ou plusieurs prot~ines associ~es ~ la virulence d'AEEC, notamment les prot~ines Eae, Tir, EspA et Paa.
Batisson Isabelle
Fairbrother John M.
Girard Francis
Guimond Marie-Pierre
Harel Josee
Robic
Valorisation-Recherche Societe En Commandite
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