Antibodies for treatment and prevention of respiratory...

Details Antibodies for treatment and prevention of respiratory... Antibodies for treatment and prevention of respiratory...

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 39/42 (2006.01) C07K 14/135 (2006.01) C07K 16/10 (2006.01) C07K 16/46 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 15/13 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2133662

2133662 9320210 PCTABS00027 The present invention provides variable light chain and variable heavy chain sequences derived from bovine anti-RSV F protein monoclonal antibodies (mAbs), B4 and B13/B14, and CDR peptides therefrom, which may be employed in the design of fusion proteins (including altered antibodies) which are charaterized by the antigen binding specificity of these mAbs. Also described is a humanized antibody containing bovine variable chain sequences. Methods for producing and using these compositions, including pharmaceutical compositions are disclosed.

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