Antibodies having a mutated amino acid residue at position...

Details Antibodies having a mutated amino acid residue at position... Antibodies having a mutated amino acid residue at position...

C - Chemistry, Metallurgy

07

K

C07K 16/00 (2006.01) A61K 39/395 (2006.01) A61P 7/08 (2006.01)

Patent

CA 2541868

Disclosed are processes for producing a variant polypeptide (e.g. antibodies) having increased binding affinity for an FcgR, which processes comprise modifying the polypeptides by substitution of the amino acid at position 268 of a human IgG CH2 region for a non-native polar or charged amino acid e.g. Gln, Asn, Glu, or Asp.

L'invention concerne des procédés pour produire un variant de polypeptide (par exemple des anticorps) présentant une affinité de liaison accrue pour FcgR, lesdits procédés consistant à modifier les polypeptides par substitution de l'acide aminé à la position 268 d'une région CH2 d'une IgG humaine par un acide aminé chargé ou polaire non natif, par exemple Gln, Asn, Glu, ou Asp. L'invention concerne également des polypeptides et acides nucléiques correspondants ainsi que des procédés d'utilisation de ces derniers par exemple dans des traitements lytiques améliorés.

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