Antibodies having dual specificities, their preparation and...

Details Antibodies having dual specificities, their preparation and... Antibodies having dual specificities, their preparation and...

G - Physics

01

N

167/41, 195/1.10

G01N 33/542 (2006.01) A61K 39/395 (2006.01) A61K 51/10 (2006.01) C07K 16/46 (2006.01) C12N 5/02 (2006.01)

Patent

CA 1213229

ABSTRACT Described herein are "polydomas", the product of the fusion of a hybridoma with a B-lymphocyte or another hybridoma. The polydomas produce a hybrid monoclonal antibody having a dual specificity against two different antigenic determinants. Also described are immunodiagnostic and immunotherapeutic pro- cesses which utilize the hybrid monoclonal antibodies or other antibodies having a dual specificity. In those processes, one specificity of the antibody is directed against a target antigen and the other against a moiety which permits a diagnosis to be made or which delivers an agent lethal to the target antigen or associated tissue.

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