C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 16/30 (2006.01) C07K 16/40 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2682093
A method of diagnosing melanoma and antibodies capable of same are disclosed. The method comprises contacting a cell of the subject with an antibody comprising an antigen recognition domain capable of binding to an MHC-I molecule being complexed with a tyrosinase peptide, wherein the antibody does not bind the MHC-I in the absence of the complexed peptide, and wherein the antibody does not bind the peptide in an absence of the MHC, under conditions which allow immunocomplex formation, wherein a presence of the immunocomplex or level thereof is indicative of the melanoma. Methods for treating melanoma and antibodies capable of same are also disclosed. Pharmaceutical compositions comprising antibodies are also disclosed.
L'invention concerne un procédé de diagnostic de mélanomes et des anticorps pouvant agir de même. Le procédé comprend la mise en contact d'une cellule du sujet avec un anticorps comprenant un domaine de reconnaissance d'un antigène capable de se lier à une molécule MHC-I qui est complexée à un peptide de tyrosinase, l'anticorps ne se liant pas à MHC-I en l'absence du peptide complexé, et l'anticorps ne se liant pas au peptide en l'absence de MHC, dans des conditions qui permettent la formation d'un immuno-complexe, la présence de l'immuno-complexe ou le niveau de celui-ci étant indicatif d'un mélanome. L'invention concerne également des procédés de traitement de mélanomes et des anticorps pouvant agir de même. L'invention concerne également des compositions pharmaceutiques comprenant les anticorps.
Cohen Cyril
Denkberg Galit
Haus-Cohen Maya
Klechevsky Eynav
Michaeli Yael
Integral Ip
Technion Research & Development Foundation Ltd.
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