Antibodies, polypeptides, production and use thereof

Details Antibodies, polypeptides, production and use thereof Antibodies, polypeptides, production and use thereof

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) A61K 38/18 (2006.01) A61K 39/395 (2006.01) C07K 14/475 (2006.01) C07K 14/50 (2006.01) C07K 16/22 (2006.01) C12N 5/18 (2006.01) C12P 21/08 (2006.01) G01N 33/566 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01) G01N 33/74 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2112046

ANTIBODIES, POLYPEPTIDES, PRODUCTION AND USE THEREOF ABSTRACT The present invention relates to a glia activating factor (GAF) in which 33 to 49 N-terminal amino acids are deleted from the N-terminus of the GAF polypeptide of SEQ ID NO: 3, as well as an anti-GAF antibody which is highly sensitive to assay the GAF and is capable of neutralizing GAF's activity, is produced. Using the antibody, GAF and its biological activity can be assayed easily with high sensitivity. Further, the neutralizing antibody can be expected to have preventive and curative effects on diseases caused by GAF's excessive action. Furthermore, the GAF polypeptide disclosed herein is more stable to acids and heat than the conventional GAFs, therefore, it can be used as a platelet-increasing agent, etc., more advantageously than the previously known GAFs.

Affiliated with

Also associated with

Rating

Antibodies, polypeptides, production and use thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antibodies, polypeptides, production and use thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antibodies, polypeptides, production and use thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1617196