Antibodies reactive with human carcinomas

Details Antibodies reactive with human carcinomas Antibodies reactive with human carcinomas

C - Chemistry, Metallurgy

12

P

167/100, 167/139

C12P 21/08 (2006.01) A61K 39/395 (2006.01) A61K 39/44 (2006.01) A61K 47/48 (2006.01) A61K 51/10 (2006.01) C07K 14/415 (2006.01) C07K 16/18 (2006.01) C07K 16/30 (2006.01) C07K 16/42 (2006.01) C07K 16/46 (2006.01) C12N 15/10 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2020247

The present invention relates to novel antibodies reactive with human carcinoma cells. More particularly, the antibodies of the invention include: a murine monoclonal antibody, BR96; a human/murine chimeric antibody, ChiBR96; and a F(ab')2 fragment of BR96. These antibodies are reactive with a cell membrane antigen on the surface of human carcinomas. The antibodies display a high degree of selectivity for carcinoma cells and possess the ability to mediate ADCC and CDC activity. In addition, the antibodies of the invention internalize within the carcinoma cells to which they bind and are therefore particularly useful for therapeutic applications, for example, as the antibody component of antibody-drug or antibody-toxin conjugates. The antibodies also have a unique feature in that they are cytotoxic when used in the unmodified form, at specified concentrations.

Affiliated with

Also associated with

Rating

Antibodies reactive with human carcinomas does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antibodies reactive with human carcinomas, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antibodies reactive with human carcinomas will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1711995