A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/00 (2006.01) A61K 38/00 (2006.01) A61K 38/16 (2006.01) A61K 39/02 (2006.01) A61K 39/085 (2006.01) A61K 39/09 (2006.01) A61K 39/38 (2006.01) C07K 1/00 (2006.01) C07K 14/00 (2006.01) C07K 17/00 (2006.01)
Patent
CA 2642984
The present invention provides MSCRAMM® proteins from S. aureus which are putative highly-expressed antigens from methicillin-resistant S. aureus, including communit -associated MRSA (CA-MRSA), and these antigens can thus be utilized in methods of generating antibodies capable of binding these antigens which can be useful in methods of treating or preventing infection from MRSA. The present invention is directed to these proteins, antibodies capable of binding these proteins, methods of generating said antibodies, nucleic acids coding for said proteins, and pharmaceutical compositions or vaccines which include the proteins or antibodies of the present invention in combination with a pharmaceutically acceptable vehicle, carrier or excipient.
La présente invention concerne des protéines MSCRAMM® de S. aureus qui sont des antigènes putatifs hautement exprimé de S. aureus résistant à la méthicilline, y compris le SARM communautaire (SARM-C). Ces antigènes peuvent donc être utilisés dans des procédés permettant de générer des anticorps capables de se lier à ces antigènes et potentiellement utiles dans des procédés de traitement ou de prévention d'infections à SARM. La présente invention concerne ces protéines, des anticorps capables de se lier à ces protéines, des procédés de production desdits anticorps, des acides nucléiques codant pour lesdites protéines, et des compositions pharmaceutiques ou des vaccins comprenant les protéines ou les anticorps de la présente invention en combinaison avec un véhicule, support ou excipient pharmaceutiquement acceptable.
Bowden M. Gabriela
Hook Magnus
Labandeira-Rey Maria
Moffat & Co.
The Texas A. & M. University System
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