Antibodies recognizing the fourth immunoglobulin-like domain...

Details Antibodies recognizing the fourth immunoglobulin-like domain... Antibodies recognizing the fourth immunoglobulin-like domain...

C - Chemistry, Metallurgy

12

P

C12P 21/08 (2006.01) A61K 39/395 (2006.01) A61K 49/00 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C07K 16/46 (2006.01) C12N 5/00 (2006.01) C12N 5/18 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2127532

2127532 9314220 PCTABS00024 Monoclonal antibodies recognizing immunoglobulin domain 4 of Vascular Cell Adhesion Molecule-1 (VCAM1) are described. Such antibodies are useful, e.g., in the treatment of acute inflammation and disorders characterized by VCAM1-mediated adhesion of leukocytes and in purification methods, diagnostic methods and diagnostic kits, especially where distinguishing between the six-domain and seven-domain forms of VCAM1 is advantageous.

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