Antibodies specific for a haemostatic protein, their use for...

C - Chemistry – Metallurgy – 12 – N

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C12N 9/64 (2006.01) A61K 38/17 (2006.01) A61K 38/36 (2006.01) A61K 38/48 (2006.01) A61P 7/00 (2006.01) C07K 1/22 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/745 (2006.01) C07K 16/36 (2006.01) C07K 16/40 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2143125

Methods for the generation of Ca2+ -independent antibodies against blood coagulation factors, employing an antibody selection strategy based on small peptides that are comprising target sequences for limited proteolysis. These antibodies, which substantially distinguish between intact and cleaved species of said haemostatic protein, provide novel tools for the isolation of intact haemostatic proteins. By virtue of the absence of cleavage products that usually are associated with side-effects or reduced efficacy, these intact proteins may serve as improved agents in therapeutic compositions for the treatment of haemostatic disorders.

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