Antibodies specific for cd4-binding domain of hiv

Details Antibodies specific for cd4-binding domain of hiv Antibodies specific for cd4-binding domain of hiv

C - Chemistry, Metallurgy

12

N

C12N 5/28 (2006.01) A61K 47/48 (2006.01) C07K 7/08 (2006.01) C07K 14/16 (2006.01) C07K 16/10 (2006.01) C07K 16/42 (2006.01) C07K 19/00 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2051107

2051107 9012868 PCTABS00002 A particular epitope located within the CD4-binding region of gp120 of HIV-1, and antibody specific for the epitope which can inhibit diverse strains and isolates of the virus, is disclosed. The antibody can be used in immunotherapy of HIV-1 infection. In addition, neutralizing antibody against this conserved epitope can be used in immunoconjugates to target virally-infected cells.

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