C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 31/00 (2006.01) A61K 47/10 (2006.01) A61K 47/48 (2006.01) A61K 51/10 (2006.01) A61P 35/00 (2006.01) A61P 35/04 (2006.01) C07K 16/46 (2006.01) C12N 5/10 (2006.01) C12N 15/13 (2006.01) C12N 15/62 (2006.01) C12N 15/63 (2006.01)
Patent
CA 2443437
The present invention belongs to the field of oncology. The invention relates to antibodies with specified sequence which are specific for an epitope which is coded by the variant exon v6 of the CD44 gene and to derivatives of said antibody. The invention also provides nucleic acid molecules encoding said antibody proteins. The invention furthermore pertains to methods for producing said antibody proteins. The invention also provides pharmaceutical compositions comprising said antibody proteins. The invention furthermore is concerned with the use in the manufacture of a medicament for the treatment of cancer.
La présente invention concerne le domaine de l'oncologie et en particulier des anticorps ayant une séquence spécifiée qui sont spécifiquement dirigés contre un épitope qui est codé par l'exon variant v6 du gène CD44 et les dérivés de cet anticorps; des molécules d'acide nucléique codant les protéines d'anticorps; des méthodes de production desdites protéines d'anticorps; des compositions pharmaceutiques comprenant lesdites protéines d'anticorps et l'utilisation de ces dernières dans la préparation d'un médicament destiné au traitement du cancer.
Adolf Guenther
Heider Karl-Heinz
Miglietta John J.
Ostermann Elinborg
Patzelt Erik
Boehringer Ingelheim International Gmbh
Boehringer Ingelheim Pharmaceuticals Inc.
Fetherstonhaugh & Co.
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