Antibodies specific for cyp1b1

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/40 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C12N 9/02 (2006.01) C12P 21/08 (2006.01) G01N 33/573 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2365121

Antibodies that can specially bind to cytochrome P450 CYP1B1 and methods of making them are disclosed, in particular antibodies that bind to amino acid sequence VNQWSVNHDPVKWPN or PFxFDPARFLDKDGy, where x is D or N and y is L or F, or an antigenic fragment thereof. The antibodies can be used in the diagnosis or treatment of cancers linked to enhanced CYP1B1 expression, including breast cancer, prostate cancer, colorectal cancer, liver cancer and ovarian cancer.

L'invention concerne des anticorps pouvant se lier spécifiquement au cytochrome P450 CYP1B1 ainsi que des méthodes de fabrication de ces anticorps. L'invention concerne en particulier des anticorps qui se lient à la séquence d'acide aminé VNQWSVNHDPVKWPN ou PExFDPARFLDKDGy, où x représente D ou N et y représente L ou F, ou un fragment antigénique correspondant. Lesdits anticorps peuvent être utilisés pour le diagnostic ou le traitement de cancers liés à une expression de CYP1B1 améliorée, notamment le cancer du sein, de la prostate, du côlon et du rectum, du foie et des ovaires.

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