Antibodies specific for dcc gene product

Details Antibodies specific for dcc gene product Antibodies specific for dcc gene product

C - Chemistry, Metallurgy

12

N

C12N 5/18 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) G01N 33/561 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2163422

Antibodies are disclosed which are able to detect the DCC protein in biological samples, despite the extremely low level of expression of DCC. Immunological methods for detecting DCC alterations are also disclosed. These reagents and methods allow detection of DCC mutations without the need to analyze this very large gene in individual test samples.

L'invention concerne des anticorps capables de détecter la protéine DCC dans des échantillons biologiques en dépit du niveau extrêment bas d'expression de DCC. Des procédés immunologiques de détection des modifications de DCC sont également décrits. Ces réactifs et ces procédés permettent de détecter les mutations de DCC sans avoir besoin d'analyser ce gène très vaste dans des échantillons individuels.

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