C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/18 (2006.01) A61K 39/395 (2006.01) A61P 19/00 (2006.01)
Patent
CA 2677356
Antibodies specific for Dkk-1, an inhibitor of the osteoanabolic Wnt/LRP5 signaling pathway, are described. The antibodies, which inhibit binding of Dkk-1 to LRP5, are useful in compositions for stimulating bone growth, in particular, compositions for treating bone disorders which result in a loss in bone, for example, osteoporosis.
La présence invention concerne des anticorps spécifiques de Dkk-1, un inhibiteur de la voie de signalisation ostéo-anabolique Wnt/LRP5. Les anticorps, qui inhibent la liaison de Dkk-1 à LRP5, sont utiles dans des compositions destinées à stimuler la croissance osseuse, en particulier, des compositions destinées au traitement de troubles osseux qui résultent d'une perte osseuse, par exemple, l'ostéoporose.
An Zhiqiang
Chen Fang
Fisher John E.
Glantschnig Helmut
Kimmel Donald B.
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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