Antibodies specific for human cd22 and their therapeutic and...

Details Antibodies specific for human cd22 and their therapeutic and... Antibodies specific for human cd22 and their therapeutic and...

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 31/7088 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12N 15/85 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2484420

There is disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human CD22. There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a modified CDR. Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases mediated by cells expressing CD22.

Cette invention, qui a trait à des molécules d'anticorps contenant au moins une région déterminante complémentaire (CDR) dérivée d'un anticorps monoclonal murin spécifique du CD22, concerne également un anticorps de CDR greffé, l'une au moins de ces régions étant modifiée. Elle porte, en outre, sur des séquences d'ADN codant les chaînes des molécules d'anticorps, des vecteurs, des cellules hôtes transformées ainsi que sur l'utilisation qui est faitede ces molécules pour le traitement d'états pathologiques liés aux cellules exprimant la (CD22).

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