Antibodies specific for native prpsc

Details Antibodies specific for native prpsc Antibodies specific for native prpsc

C - Chemistry, Metallurgy

07

K

C07K 16/18 (2006.01) G01N 33/543 (2006.01) G01N 33/569 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2231409

Prions are infectious pathogens that cause central nervous system spongiform encephalopathies in humans and animals. The current invention relates to methods for obtaining antibodies which specifically bind to naturally occurring scrapie isoform of prion protein (PrPSc) and to methods for using the antibodies in detecting PrPSc in samples.

Les prions sont des pathogènes infectieux responsables des encéphalopathies spongiformes du système nerveux central chez l'homme et chez les animaux. L'invention concerne des procédés d'obtention d'anticorps qui se fixent spécifiquement à l'isoforme naturelle du prion protéinique (PrP?Sc¿) responsable de la tremblante du mouton et des procédés d'utilisation d'anticorps pour la détection de PrP?Sc¿ dans des échantillons.

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