C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/18 (2006.01) A61K 39/395 (2006.01) A61P 25/28 (2006.01) C07K 14/47 (2006.01)
Patent
CA 2570130
The invention pertains to the development of antibodies that specifically bind amyloid beta protein (Abeta) in its protofibril conformation. The invention also comprises methods of using anti-Abeta protofibril antibodies to diagnose or treat Alzheimer's disease, Down's syndrome Lewybody dementia, vascular dementia, and other neurodegenerative disorders. Furthermore, the invention pertains to the use of anti-Abeta protofibril antibodies to screen and identify substances that will modulate protofibril activity or formation in vitro or in vivo. The invention also pertains to methods for synthesising pure Abeta protofibril antigens as well as to a method for stabilising Abeta protofibrils antigens as well as to a method for stabilising Abeta protofibrils.
L'invention concerne le développement d'anticorps se liant de manière spécifique à la protéine amyloïde bêta (Abêta) dans sa conformation de protofibrille. L'invention concerne également des procédés d'utilisation des anticorps de protofibrilles anti-Abêta, aux fins de diagnostic ou de traitement de la maladie d'Alzheimer, du syndrome de Down, de la démence à corps de Lewy, de la démence vasculaire et d'autres troubles neurodégénératifs. De plus, l'invention concerne l'utilisation des anticorps de protofibrilles anti-Abêta, aux fins de criblage et d'identification de substances modulant l'activité ou la formation de protofibrilles in vitro<i> </i>ou<i> </i>in vivo. L'invention concerne enfin des procédés de synthèse des antigènes purs de protofibrilles d'Abêta, ainsi qu'un procédé de stabilisation de protofibrilles d'Abêta.
Gellerfors Par
Lannfelt Lars
Bioarctic Neuroscience Ab
Cassan Maclean
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