Antibodies specific for the complex of interleukin-6 and the...

C - Chemistry – Metallurgy – 07 – K

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C07K 16/24 (2006.01) A61K 39/395 (2006.01) C07K 16/28 (2006.01) C12N 15/13 (2006.01)

Patent

CA 2670583

Binding members, especially antibody molecules that bind the IL-6 :IL-6Ra complex formed by IL-6 and IL-6Ra, and do not bind either IL-6 or IL-6Ra alone. The binding members may have greater specificity for inhibiting pathological effects of IL-6 rather than beneficial effects of IL-6, as compared with binding members that bind IL-6 or IL-6Ra outside the IL-6: IL-6Ra complex.

Eléments de liaison, en particulier des molécules d'anticorps qui se lient au complexe IL-6 :IL-6Ra formé par IL-6 et IL-6Ra, et ne se lient pas à IL-6 ou IL-6Ra individuellement. Les éléments de liaison peuvent présenter une spécificité supérieure pour inhiber les effets pathologiques de IL-6 plutôt que les effets bénéfiques de IL-6, par rapport aux éléments de liaison qui se lient à IL-6 ou IL-6Ra en dehors du complexe IL-6: IL-6Ra.

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