C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2759538
The present disclosure provides antibodies, including iso-lated monoclonal antibodies, which specifically bind to Cadherin-17 with high affinity. Nucleic acid molecules encoding Cadherin-17 antibodies, ex- pression vectors, host cells and methods for expressing the Cadherin-17 antibodies are also provided. Bispecific molecules and pharmaceutical compositions comprising the Cadherin-17 antibodies are also provided. Methods for detecting Cadherin-17, as well as methods for treating various cancers, including colorectal cancer, are disclosed.
La présente invention concerne des anticorps, y compris des anticorps monoclonaux isolés, qui se lient spécifiquement à la cadhérine-17 avec une affinité élevée. L'invention porte en outre sur des molécules d'acide nucléique codant pour les anticorps de la cadhérine-17, des vecteurs d'expression, des cellules hôtes et des méthodes d'expression des anticorps de la cadhérine-17. La présente invention concerne également des molécules bispécifiques et des compositions pharmaceutiques comprenant lesdits anticorps de cadhérine-17. L'invention concerne par ailleurs la détection de la cadhérine-17, ainsi que des méthodes de traitement de divers cancers, y compris le cancer colorectal.
Rohlff Christian
Terrett Jonathan Alexander
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Oxford Biotherapeutics Ltd
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