C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/22 (2006.01) A61K 39/395 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2703154
The present invention provides antibodies, as well as molecules having at least the antigen-binding portion of an antibody, against agonist pro-angiogenic, pro-permeability, vasodilatory isoforms of VEGF. Disclosed antibodies and antibody fragments are characterized by being capable of binding to and neutralizing pro-angiogenic forms of VEGF while not effecting isoforms of VEGF which are anti angiogenic. Methods of production and use in therapy and diagnosis, of such antibodies and antibody fragments are also provided.
L'invention concerne des anticorps, ainsi que des molécules comprenant au moins la partie de liaison à l'antigène d'un anticorps, dirigés contre les isoformes pro-angiogéniques, pro-perméabilité, vasodilatatoires du VEGF. Les anticorps et fragments d'anticorps de l'invention sont caractérisés en ce qu'ils sont capables de se lier à des formes pro-angiogéniques du VEGF et deneutraliser ces dernières tout en n'agissant pas sur les isoformes anti-angiogéniques du VEGF. L'invention porte également sur des procédés de production et d'utilisation desdits anticorps et fragments d'anticorps à des fins de thérapie et de diagnostic.
Bates David O.
Harper Steven J.
Mangelus Miriam Y.
Ze'evi Menachem
Fasken Martineau Dumoulin Llp
Philogene Inc.
University Of Bristol
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