Antibodies that bind both bcma and taci

Details Antibodies that bind both bcma and taci Antibodies that bind both bcma and taci

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01) C07K 16/46 (2006.01)

Patent

CA 2438682

Molecules that interfere with the binding of a tumor necrosis factor receptor with its ligand, such as a soluble receptor or an anti-receptor antibody, have proven usefulness in both basic research and as therapeutics. The present invention provides antibodies that bind two tumor necrosis factor receptor family members: the transmembrane activator and calcium modulator and cyclophilin ligand-interactor (TACI) receptor, and the B-cellmaturation (BCMA) receptor.

Des molécules qui gênent la liaison d'un récepteur de facteur de nécrose tumorale avec son ligand, tel qu'un récepteur soluble ou un anticorps anti-récepteur, ont prouvé leur utilité, à la fois dans la recherche fondamentale et dans la thérapeutique. L'invention concerne des anticorps qui lient deux membres de la famille des récepteurs de facteur de nécrose tumorale: le récepteur TACI, activateur transmembranaire modulant le calcium et interagissant sur le ligand de cyclophiline, et le récepteur BCMA de maturation de cellule B.

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