Antibodies that bind cell-associated ca 125/o772p and...

C - Chemistry – Metallurgy – 07 – K

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C07K 16/00 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07H 21/04 (2006.01) C07K 16/30 (2006.01) C12N 5/12 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2502367

The present invention provides antibodies, and antigen-binding fragments of antibodies, fusion polypeptides and analogs that preferentially bind cell- associated CA 125/0772P polypeptides relative to shed CA 125/0772P polypeptides. The present invention further provides methods of preventing, managing, treating or ameliorating one or more symptoms associated with a CA 125/0772P-related disorder. In particular, the present invention provides methods of preventing, managing, treating, or ameliorating one or more symptoms associated with a cell proliferative disorder, such as cancer, e.g., ovarian cancer. The present invention still further provides methods for diagnosing a CA 125/0772P-related disorder or predisposition to developing such a disorder, as well as methods for identifying antibodies, and antigen- binding.fragments of antibodies, that preferentially bind cell-associated CA 125/0772P polypeptides relative to shed CA 125/0772P polypeptides.

L'invention concerne des anticorps ainsi que des fragments d'anticorps à liaison antigénique, des polypeptides de fusion et des analogues qui se fixent préférentiellement sur des polypeptides CA 125/0772P associés à des cellules que sur des polypeptides CA 125/0772P libérés. L'invention se rapporte également à des procédés permettant de prévenir, gérer, traiter ou améliorer un ou plusieurs symptôme(s) associé(s) à un trouble lié aux polypeptides CA 125/0772P. En particulier, cette invention concerne des procédés permettant de prévenir, gérer, traiter ou améliorer un ou plusieurs symptôme(s) associé(s) à un trouble de la prolifération cellulaire, tel que le cancer, par ex. le cancer de l'ovaire. La présente invention se rapporte en outre à des procédés permettant de diagnostiquer un trouble lié aux polypeptides CA 125/0772P ou une prédisposition à développer un tel trouble, ainsi qu'à des procédés permettant d'identifier des anticorps et des fragments d'anticorps à liaison antigénique qui se fixent préférentiellement sur des polypeptides CA 125/0772P associés à des cellules que sur des polypeptides CA 125/0772P libérés.

LandOfFree

Say what you really think

Search LandOfFree.com for Canadian inventors and patents. Rate them and share your experience with other people.

Rating

Antibodies that bind cell-associated ca 125/o772p and... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antibodies that bind cell-associated ca 125/o772p and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antibodies that bind cell-associated ca 125/o772p and... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFCA-PAI-O-1854915

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.