Antibodies that bind to cancer-associated antigen cd46 and...

Details Antibodies that bind to cancer-associated antigen cd46 and... Antibodies that bind to cancer-associated antigen cd46 and...

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 38/16 (2006.01) A61K 39/395 (2006.01) A61K 39/44 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07K 16/30 (2006.01) C07K 16/46 (2006.01) C12N 5/10 (2006.01) C12P 21/08 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2463927

Provided herein is disclosure about the development and characterization of . an antibody (mP A 7) which binds to antigen CD46 which is present on a variety of human cancers from ovary, breast, lung, prostate, colon, kidney, and pancreas. Methods of diagnosing and treating various cancers by using antibodies such as mP A 7 directed against this antigen are also disclosed.

L'invention concerne le développement et la caractérisation d'un anticorps (mPA7) se liant à un antigène CD46 présent dans une pluralité de cancers humains, tels que le cancer de l'ovaire, du sein, du poumon, de la prostate, du côlon, du rein et du pancréas. L'invention concerne également des méthodes de diagnostic et de traitement d'une pluralité de cancers au moyen d'anticorps tels que mPA7 dirigés contre cet antigène.

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