Antibodies that bind to integrin alpha-v-beta-6 and methods...

Details Antibodies that bind to integrin alpha-v-beta-6 and methods... Antibodies that bind to integrin alpha-v-beta-6 and methods...

C - Chemistry, Metallurgy

12

N

C12N 5/20 (2006.01) A61K 39/395 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C07K 17/06 (2006.01) C12N 1/04 (2006.01) G01N 33/547 (2006.01)

Patent

CA 2481922

The invention provides monoclonal antibody mBLA3 that binds to integrin .alpha.v.beta.6 and other equivalent antibodies. The invention also provides the identification and characterization of cancer-associated antigen, integrin .alpha.v.beta.6, with various human cancers and methods of diagnosing and treating these human cancers.

L'invention concerne un anticorps monoclonal mBLA3 se liant à l'intégrine .alpha.v.beta.6 et d'autres anticorps équivalents. L'invention concerne également l'identification et la caractérisation d'un antigène associé au cancer, soit l'intégrine .alpha.v.beta.6, avec divers cancers humains, ainsi que des méthodes de diagnostic et de traitement de ces cancers humains.

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