C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/18 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) C07K 16/46 (2006.01) C12N 5/20 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2278477
Monoclonal and polyclonal antibodies are disclosed as well as parts thereof which bind specifically to the nidogen-binding domain of laminin, as well as a process for producing the same and their use as medicaments, as diagnostic agents for detecting laminin isoforms and as model substances for developing and evaluating substances that influence the nidogen-laminin interaction. The disclosed antibodies or their parts bind preferably to the .gamma.1 III 4- domain of laminin, in particular in the highly preserved area of loops a and c, and can inhibit the association of laminin and nidogen.
L'invention concerne des anticorps monoclonaux et polyclonaux et leurs parties qui se lient spécifiquement au domaine de liaison de nidogène de la laminine, leur procédé de production et leur utilisation comme médicaments, comme agents de diagnostic permettant de détecter des isoformes de la laminine et comme substances modèles permettant de développer et d'évaluer des substances qui affectent l'interaction entre le nidogène et la laminine. Ces anticorps ou leurs parties se lient de préférence au domaine .gamma.1 III 4 de la laminine, surtout dans le domaine très conservé des boucles a et c, et peuvent inhiber l'association de la laminine au nidogène.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Hoechst Aktiengesellschaft
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