Antibodies that immunospecifically bind to trail receptors

Details Antibodies that immunospecifically bind to trail receptors Antibodies that immunospecifically bind to trail receptors

A - Human Necessities

61

K

A61K 39/395 (2006.01) C07K 16/00 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2494372

The present invention relates to antibodies and related molecules that immunospecifically bind to TRAIL receptor, TR4. Such antibodies have uses, for example, in the prevention and treatment of cancers and other proliferative disorders. The invention also relates to nucleic acid molecules encoding anti- TR4 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer and other hyperproliferative disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to TRAIL receptor TR4.

L'invention concerne des anticorps et des molécules apparentées se fixant de façon immunospécifique au récepteur TRAIL, TR4. Ces anticorps peuvent être, par exemple, mis en application pour la prévention et le traitement de cancers ou d'autres maladies prolifératives. Elle concerne également des molécules d'acides nucléiques codant des anticorps anti-TR4, des vecteurs et des cellules hôtes contenant ces acides nucléiques et des méthodes servant à les produire. Elle concerne également des méthodes et des compositions servant à prévenir, détecter, diagnostiquer, traiter ou améliorer un trouble ou une maladie, en particulier, le cancer ou d'autres maladies hyperprolifératives, ce qui consiste à administrer à un animal, de préférence un humain, une quantité efficace d'un ou plusieurs anticorps ou fragments ou variantes de ces anticorps, ou des molécules apparentées, se fixant de manière immunospécifique au récepteur TRAIL, TR4.

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