Antibodies that immunospecifically bind to trail receptors

Details Antibodies that immunospecifically bind to trail receptors Antibodies that immunospecifically bind to trail receptors

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C12N 5/16 (2006.01) G01N 33/566 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2471140

The present invention relates to antibodies and related molecules that immunospecifically bind to TRAIL receptor, TR7. Such antibodies have uses, for example, in the prevention and treatment of cancers and other proliferative disorders. The invention also relates to nucleic acid molecules encoding anti- TR7 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer and other hyperproliferative disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to TRAIL receptor TR7.

La présente invention concerne des anticorps et des molécules correspondantes qui se lient de manière immunospécifique au récepteur TRAIL, appelé TR7. Ces anticorps peuvent être utilisés, par exemple, dans la prévention et le traitement des cancers et d'autres maladies prolifératives. Cette invention se rapporte également à des molécules d'acides nucléiques codant des anticorps anti-TR7, des vecteurs et des cellules hôtes contenant ces acides nucléiques et des méthodes de production de ces derniers; des méthodes et des compositions utilisées pour la prévention, la détection, le diagnostic, le traitement ou l'amélioration d'une maladie ou d'un trouble, plus spécifiquement le cancer et d'autres maladies hyperprolifératives, qui consistent à administrer à un animal, de préférence un homme, une quantité efficace d'au moins un anticorps ou bien de fragments ou de variants de ce dernier, ou encore des molécules apparentées, qui se lient de manière immunospécifique au récepteur TRAIL TR7.

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