Antibodies that immunospecifically bind to trail receptors

Details Antibodies that immunospecifically bind to trail receptors Antibodies that immunospecifically bind to trail receptors

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07K 17/00 (2006.01) C12N 5/12 (2006.01) A61K 31/337 (2006.01) A61K 31/475 (2006.01) A61K 31/7068 (2006.01)

Patent

CA 2524737

The present invention relates to antibodies and related molecules that immunospecifically bind to TRAIL receptor, TR7. Such antibodies have uses, for example, in the prevention and treatment of cancers and other proliferative disorders. The invention also relates to nucleic acid molecules encoding anti- TR7 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer and other hyperproliferative disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to TRAIL receptor TR7.

La présente invention concerne des anticorps et des molécules associées se liant de manière immunospécifique au récepteur TRAIL TR7. Ces anticorps trouvent une utilisation, par exemple, dans la prévention et le traitement de cancers et d'autres pathologies prolifératives. L'invention concerne également des molécules d'acides nucléiques codant pour des anticorps dirigés contre TR7, des vecteurs et des cellules hôtes contenant ces acides nucléiques, ainsi que des méthodes de production correspondantes. La présente invention concerne des méthodes et des compositions destinées à prévenir, détecter, diagnostiquer, traiter ou atténuer une maladie ou une pathologie, et notamment le cancer et d'autres pathologies hyperprolifératives. Ces méthodes consistent à administrer à un animal, de préférence à un être humain, une dose efficace d'un ou plusieurs anticorps ou fragments ou variants de ceux-ci, ou des molécules associées, se liant de manière immunospécifique au récepteur TRAIL TR7.

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