Antibodies that immunospecifically bind to trail receptors

Details Antibodies that immunospecifically bind to trail receptors Antibodies that immunospecifically bind to trail receptors

A - Human Necessities

61

K

A61K 39/00 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2426710

The present invention relates to antibodies and related molecules that immunospecifically bind to TRAIL receptors. Such antibodies have uses, for example, in the prevention and treatment of cancers and other proliferative disorders. The invention also relates to nucleic acid molecules encoding anti- TRAIL receptor antibodies, vectors, and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer and other hyperproliferative disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to TRAIL receptor.

L'invention concerne des anticorps et des molécules connexes à liaison immunospécifique avec les récepteurs TRAIL. Ces anticorps sont utiles, par exemple, dans la prévention et le traitement du cancer et autres troubles proliférants. L'invention concerne également des molécules d'acides nucléiques codant des anticorps vis-à-vis des récepteurs TRAIL, des vecteurs et des cellules hôtes renfermant ces acides nucléiques, et des procédés relatifs à leur élaboration. L'invention concerne en outre des procédés et des compositions pour la prévention, la détection, le diagnostic, le traitement ou l'amélioration d'une maladie ou d'un trouble, en particulier le cancer et autres troubles hyperproliférants: on administre à un animal, de préférence un être humain, une quantité efficace d'un ou plusieurs anticorps ou bien de fragments ou de variants correspondants, ou encore des molécules connexes, à capacité de liaison spécifique avec le récepteur TRAIL.

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