Antibodies that neutralize botulinum neurotoxins

Details Antibodies that neutralize botulinum neurotoxins Antibodies that neutralize botulinum neurotoxins

C - Chemistry, Metallurgy

07

K

C07K 16/12 (2006.01) A61K 39/40 (2006.01) A61P 39/02 (2006.01) C12N 15/13 (2006.01) C07K 16/40 (2006.01)

Patent

CA 2732003

This disclosure provides antibodies that specifically bind to and typically neutralize botulinum neurotoxins (e.g., BoNT/A, BoNT/B, BoNT/E, etc.) and the epitopes bound by those antibodies. The antibodies and derivatives thereof and/or other antibodies that specifically bind to the neutralizing epitopes provided herein can be used to neutralize botulinum neurotoxin and are therefore also useful in the treatment of botulism.

Cette invention porte sur des anticorps qui se lient spécifiquement à et neutralisent typiquement des neurotoxines botuliniques (par exemple, BoNT/A, BoNT/B, BoNT/E, etc.) et sur les épitopes liés à ces anticorps. Les anticorps et dérivés de ceux-ci et/ou autres anticorps qui se lient spécifiquement aux épitopes neutralisants fournis ici peuvent être utilisés pour neutraliser une neurotoxine botulinique et sont par conséquent également utiles dans le traitement du botulisme.

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