C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/18 (2006.01) A61K 39/00 (2006.01) C07K 14/47 (2006.01) C07K 16/28 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2363984
Amyloid-.beta. peptide (A.beta.) formation and the apoptotic loss of neurons are intimately linked processes in the pathogenesis of neurodegenerative diseases, particularly Alzheimer's disease. The roles of apoptotic proteases and caspases in cleavage of amyloid-.beta. precursor protein (APP) and biogenesis of amyloidogenic A.beta. peptide species are described. Antibodies that recognize caspase cleaved APP are described as well as various utilities therefore.
La formation du peptide .beta.-amyloïde (A.beta.) et la perte de neurones par apoptose sont des processus intimement liés dans la pathogénèse des maladies neurodégénératives, et notamment la maladie d'Alzheimer. L'invention concerne les rôles des protéases et caspases apoptotiques dans le clivage de la protéine précurseur amyloïde-.beta. (APP) et dans la biogénèse des espèces peptidiques amyloïdogènes A.beta.. L'invention concerne également des anticorps reconnaissant l'APP clivée par une caspase, ainsi que leurs nombreuses utilisations.
Gervais Francois
Huang Jingqi
Nicholson Donald W.
Robertson George
Roy Sophie
Merck Frosst Canada Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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