C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/00 (2006.01) A61P 9/10 (2006.01) C07K 16/18 (2006.01)
Patent
CA 2758994
The present invention relates to the field of biotechnology and particularly to novel products for use in human health. The present invention provides novel monoclonal antibodies that specifically and with high affinity recognize sulphatides and sulphated proteoglycans. The anti-sulphatide and anti-sulphated proteoglycan antibodies described in the present specification constitute important diagnostic and therapeutic agents for acting on pathological processes associated with the appearance of atherosclerotic plaques. According thereto, the invention provides pharmaceutical compositions that comprise the monoclonal antibodies of the invention or fragments derived from these antibodies for therapeutic and diagnostic use in association with cardiovascular diseases. Additionally, the present invention relates to fragments of the monoclonal antibodies that recognize sulphatides and sulphated proteoglycans, such that said fragments may be used in the treatment or diagnosis of this pathological condition.
La présente invention concerne le domaine de la biotechnologie, et notamment de nouveaux produits destinés à être utilisés en prophylaxie humaine. La présente invention concerne de nouveaux anticorps monoclonaux qui reconnaissent de manière spécifique et avec une affinité élevée des sulfatides et des protéoglycanes sulfatés. Les anticorps anti-sulfatides et anti-protéoglycanes sulfatés décrits dans cette invention constituent d'importants agents diagnostiques et thérapeutiques pour agir sur des processus pathologiques associés à l'apparition de plaques d'athérosclérose. Aussi, l'invention concerne des compositions pharmaceutiques qui renferment les anticorps monoclonaux de l'invention ou les fragments dérivés de ces anti-corps destinés à être utilisés à des fins thérapeutiques et diagnostiques associées à des maladies cardiovasculaires. En outre, l'invention a trait aux fragments des anticorps monoclonaux qui reconnaissent des sulfatides et des protéoglycanes sulfatés, de sorte que lesdits fragments puissent être utilisés pour le traitement ou le diagnostic de cette pathologie.
Brito Navarro Victor
de Acosta Del Rio Cristina Mateo
Fernandez Marrero Yuniel
Lopez Requena Alejandro
Soto Lopez Yosdel
Centro de Inmunologia Molecular
Macrae & Co.
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