C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 31/7088 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 16/18 (2006.01) C07K 16/30 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2740900
Novel monoclonal antibodies that specifically bind to KAAG1 are described. In some embodiments, the antibodies block the biological activity of KAAG1 and are useful in composition in certain cancers, more particularly in cancers that have increased cell surface expression of KAAG1, such as ovarian, renal, lung, colorectal, breast, brain, and prostate cancer, as well as melanoma. The invention also relates to cells expressing the monoclonal antibodies and antigen binding fragments such as humanized and chimeric antibodies. Additionally, methods of detecting and treating cancer using the antibodies and fragments are also disclosed.
La présente invention concerne de nouveaux anticorps monoclonaux qui se lient spécifiquement à KAAG1. Dans certains modes de réalisation, les anticorps bloquent lactivité biologique de KAAG1 et sont utiles dans une composition dans certains cancers, plus particulièrement dans des cancers qui ont une expression de surface cellulaire augmentée de KAAG1, tels que le cancer ovarien, rénal, des poumons, colorectal, du sein, du cerveau, et de la prostate, ainsi quun mélanome. Linvention concerne en outre des cellules exprimant les anticorps monoclonaux et des fragments de liaison dantigène tels que des anticorps humanisés et chimériques. La présente invention concerne en outre des procédés de détection et de traitement du cancer utilisant les anticorps et fragments.
Filion Mario
Sulea Traian
Tremblay Gilles Bernard
Alethia Biotherapeutics Inc.
Forget Janique
National Research Council Of Canada
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