Antibodies to alphavbeta3 integrin

Details Antibodies to alphavbeta3 integrin Antibodies to alphavbeta3 integrin

C - Chemistry, Metallurgy

12

N

C12N 5/18 (2006.01) A61K 38/00 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07K 16/28 (2006.01) C12P 21/08 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01) C12N 15/13 (2006.01)

Patent

CA 2132091

The invention relates to monoclonal antibodies to the av.beta.3 integrin receptor known to be expressed in large amounts on the surface of osteoclasts and accordingly, associated with bone resorption. The disclosed monoclonal antibodies are believed to recognize unique epitopes on av.beta.3 and are useful in the treatment of conditions associated with excessive bone resorption and/or in the inhibition of tumor cell growth.

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