C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/22 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 51/10 (2006.01) C12N 5/16 (2006.01) C12N 15/13 (2006.01) C12P 21/08 (2006.01) C07K 14/51 (2006.01)
Patent
CA 2662350
The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, which specifically bind to BMP2, BMP4, BMPRlA, BMPRlB, ACTRl, and/or BMPR2 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Also provided are immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention and, optionally, one or more additional therapeutic. The invention also provides methods for treating diseases associated with abnormal bone formation and ossification mediated by BMP2, -BMP4, BMPRlA, BMPRlB, ACTRl5 and/or BMPR2.
La présente invention concerne des anticorps monoclonaux isolés, en particulier des anticorps monoclonaux humains, lesquels se lient spécifiquement à BMP2, BMP4, BMPR1A, BMPR1B, ACTR1 et/ou BMPR2 avec une affinité élevée. L'invention concerne également des molécules d'acide nucléique codant pour les anticorps de l'invention, des vecteurs d'expression, des cellules hôtes et des procédés servant à exprimer les anticorps de l'invention. L'invention concerne également des immunoconjugués, des molécules bispécifiques et des compositions pharmaceutiques comprenant les anticorps de l'invention et, éventuellement, un ou plusieurs agents thérapeutiques supplémentaires. L'invention concerne également des procédés servant à traiter des maladies associées à une formation osseuse et à une ossification anormales faisant intervenir BMP2, BMP4, BMPR1A, BMPR1B, ACTR1 et/ou BMPR2.
Bell Alasdair F.
Leblanc Heidi N.
Selby Mark
Singh Sujata
Sproul Timothy William
Medarex Inc.
Smart & Biggar
Zimmerman Deborah L.
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