Antibodies to c-met

Details Antibodies to c-met Antibodies to c-met

A - Human Necessities

61

K

A61K 39/395 (2006.01) C07H 21/04 (2006.01) C07K 16/00 (2006.01) C12P 21/00 (2006.01)

Patent

CA 2534563

The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that specifically bind to c-Met, preferably human c-Met, and that function to inhibit c-Met. The invention also relates to human anti-c-Met antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-c-Met antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-c-Met antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-c-Met antibodies. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.

La présente invention concerne des anticorps tels que des anticorps humains et des parties de liaison antigénique de ces derniers qui se lient spécifiquement à c-Met, de préférence c-Met humain et qui agissent pour inhiber c-Met. Cette invention se rapporte également à des anticorps anti-c-Met et à des parties de liaison antigénique de ces derniers; à des anticorps qui sont des anticorps chimères, bispécifiques, dérivés, à chaîne unique ou à des parties de protéines hybrides; à des immunoglobulines isolées à chaîne lourde et à chaîne légère dérivées d'anticorps anti-c-Met humains et à des molécules d'acide nucléique codant de telles immunoglobulines; à des méthodes de production d'anticorps anti-c-Met humains, de compositions comprenant ces anticorps et à des méthodes d'utilisation des anticorps et des compositions à des fins de diagnostic et de traitement; à des méthodes thérapie génique dans lesquelles on utilise des molécules d'acide nucléique codant les molécules d'immunoglobuline lourde et/ou légère qui comprennent les anticorps anti-c-Met humains; et à des animaux ou des plantes transgéniques comprenant les molécules d'acide nucléique selon la présente invention.

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